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Joint Societies Article Collection

Reflecting the increasingly interdisciplinary nature of life science research, this collection brings together articles published in the journals from 5 of the leading Societies in the field. Key themes highlighted include Cancer physiology and treatments, Drug resistance, Gut-brain axis, Immunology and immunotherapy, Multimorbidities and Neurodegenerative diseases.


Cancer physiology and treatments

PHLPPing the balance: restoration of protein kinase C in cancer
Biochemical Journal

Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice
Biochemical Journal

Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments
Biochemical Society Transactions

Promotion of cancer cell stemness by Ras
Biochemical Society Transactions

The DNA methylation landscape in cancer
Essays in Biochemistry

Oxytocin mediates the beneficial effects of the exercise training on breast cancer
Experimental Physiology

Assessment of endothelial dysfunction by flow‐mediated dilatation in men on long‐term androgen deprivation therapy for prostate cancer
Experimental Physiology

How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen‐dependent pathologies
Physiological Reports

Docetaxel does not impair skeletal muscle force production in a murine model of cancer chemotherapy
Physiological Reports

Acute high intensity interval exercise reduces colon cancer cell growth
The Journal of Physiology

Nuances to precision dosing strategies of targeted cancer medicines
Pharmacology Research & Perspectives

Enriching cancer pharmacology with drugs of marine origin
British Journal of Pharmacology

Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation
British Journal of Pharmacology

The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets
British Journal of Pharmacology

Clinical and translational pharmacology of drugs for the prevention and treatment of bone metastases and cancer‐induced bone loss
British Journal of Clinical Pharmacology

The relationship between sunitinib exposure and both efficacy and toxicity in real‐world patients with renal cell carcinoma and gastrointestinal stromal tumour
British Journal of Clinical Pharmacology

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response
British Journal of Clinical Pharmacology


Drug resistance

How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?
Biochemical Journal

Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis
Biochemical Society Transactions

Resolution of drug-resistant hypertension by adrenal vein sampling-guided adrenalectomy: a proof-of-concept study
Clinical Science

Antimicrobial resistance: the good, the bad, and the ugly
Emerging Topics in Life Sciences

Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
Essays in Biochemistry

Resistance of osteosarcoma cells to the proapoptotic effects of carfilzomib involves activation of mitogen activated protein kinase pathways
Experimental Physiology

Drug Extrusion, 125I− Efflux and the Control of Intracellular [Ca2+] in Drug‐Resistant Ovarian Epithelial Cells
Experimental Physiology

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine
Physiological Reports

Molecular changes during TGFβ‐mediated lung fibroblast‐myofibroblast differentiation: implication for glucocorticoid resistance
Physiological Reports

Opioid‐resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat
The Journal of Physiology

Advances and roadblocks in the treatment of malaria
British Journal of Clinical Pharmacology

The Importance of Ras in Drug Resistance in Cancer
British Journal of Pharmacology

Understanding the drug exposure–response relationship of bedaquiline to predict efficacy for novel dosing regimens in the treatment of multidrug‐resistant tuberculosis
British Journal of Clinical Pharmacology

Biological features, gene expression profile, and mechanisms of drug resistance of two‐ and three‐dimensional hepatocellular carcinoma cell cultures
Pharmacology Research & Perspectives

Vancomycin is commonly under‐dosed in critically ill children and neonates
British Journal of Clinical Pharmacology


Gut-brain axis

Advances in modelling the human microbiome–gut–brain axis in vitro
Biochemical Society Transactions

Mechanism of gut microbiota and Axl/SOCS3 in experimental autoimmune encephalomyelitis
Bioscience Reports

Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease
Clinical Science

Brain angiotensin converting enzyme-2 in central cardiovascular regulation
Clinical Science

Acute effects of increased gut microbial fermentation on the hypoxic ventilatory response in humans
Experimental Physiology

Lactobacillus rhamnosus GG soluble mediators ameliorate early life stress-induced visceral hypersensitivity and changes in spinal cord gene expression
Neuronal Signaling

Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model
Physiological Reports

Intra‐gastrointestinal amyloid‐β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology
The Journal of Physiology

Protease‐dependent excitation of nodose ganglion neurons by commensal gut bacteria
Journal of Physiology

Nod‐like receptors are critical for gut–brain axis signalling in mice
The Journal of Physiology

Nutraceuticals as modulators of gut microbiota: Role in therapy
British Journal of Pharmacology


Immunology and immunotherapy

Molecular and structural basis for Lewis glycan recognition by a cancer-targeting antibody
Biochemical Journal

Immunotherapy: enhancing the efficacy of this promising therapeutic in multiple cancers
Clinical Science

Vaccine implants: current status and recent advancements
Emerging Topics in Life Sciences

Alerting the immune system to DNA damage: micronuclei as mediators
Essays in Biochemistry

Application of single-cell RNA sequencing methodologies in understanding haematopoiesis and immunology
Essays in Biochemistry

Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNFα‐ and NOX2‐dependent pathway
Experimental Physiology

Effects of IFN‐γ on immune cell kinetics during the resolution of acute lung injury
Physiological Reports

The NRF2 stimulating agent, tin protoporphyrin, activates protective cytokine pathways in healthy human subjects and in patients with chronic kidney disease
Physiological Reports

PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines
The Journal of Physiology

Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice
The Journal of Physiology

Bone sarcomas in the immunotherapy era
British Journal of Pharmacology

Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28
British Journal of Pharmacology

Novel strategies in immune checkpoint inhibitor drug development: How far are we from the paradigm shift?
British Journal of Clinical Pharmacology

The pharmacology and therapeutic applications of monoclonal antibodies
Pharmacology Research & Perspectives

Tackling COVID‐19 infection through complement‐targeted immunotherapy
British Journal of Pharmacology

Radiation therapy and the innate immune response: Clinical implications for immunotherapy approaches
British Journal of Clinical Pharmacology


Multimorbidities

Allostatic load and ageing: linking the microbiome and nutrition with age-related health
Biochemical Society Transactions

Prognostic factors and predictors of outcome in patients with COVID-19 and related pneumonia: a retrospective cohort study
Bioscience Reports

Vascular biomedicine in an era of chronic disease and multimorbidity
Clinical Science

Developments in molecular epidemiology of aging
Emerging Topics in Life Sciences

Approaches for extending human healthspan: from antioxidants to healthspan pharmacology
Essays in Biochemistry

Combination of quercetin and exercise training attenuates depression in rats with 1,2‐dimethylhydrazine‐induced colorectal cancer: Possible involvement of inflammation and BDNF signalling
Experimental Physiology

Chronic type 2 but not type 1 diabetes impairs myocardial ischaemic tolerance and preconditioning in C57Bl/6 mice
Experimental Physiology

Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults
Experimental Physiology

Impact of severe obesity on exercise performance in heart failure with preserved ejection fraction
Physiological Reports

Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y
The Journal of Physiology

Long‐term trajectories of medicine use among older adults experiencing polypharmacy in Australia
British Journal of Clinical Pharmacology

Medication use among older people in Europe: Implications for regulatory assessment and co‐prescription of new medicines
British Journal of Clinical Pharmacology

Prescribing medicines to older people—How to consider the impact of ageing on human organ and body functions
British Journal of Clinical Pharmacology

Outcomes of deprescribing interventions in older patients with life‐limiting illness and limited life expectancy: A systematic review
British Journal of Clinical Pharmacology


Neurodegenerative diseases

Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease
Biochemical Journal

A freeze-and-thaw induced-fragment of the microtubule-associated protein Tau in rat brain extracts: implications for the biochemical assessment of neurotoxicity
Bioscience Reports

Expanding spectrum of prion diseases
Emerging Topics in Life Sciences

Respiratory disturbances in a mouse model of Parkinson's disease
Experimental Physiology

New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side
Neuronal Signaling

Modulation of CRMP2 via ( S )-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease
Neuronal Signaling

Glucagon‐like peptide‐1 analog improves neuronal and behavioral impairment and promotes neuroprotection in a rat model of aluminum‐induced dementia
Physiological Reports

Rescue of degenerating neurons and cells by stem cell released molecules: using a physiological renormalization strategy
Physiological Reports

Spinal motoneurones are intrinsically more responsive in the adult G93A SOD1 mouse model of amyotrophic lateral sclerosis
The Journal of Physiology

Altered synaptic and firing properties of cerebellar Purkinje cells in a mouse model of ARSACS
The Journal of Physiology

CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease
British Journal of Pharmacology

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities
British Journal of Pharmacology

Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease
Pharmacology Research & Perspectives

Sigma 1 receptor as a therapeutic target for amyotrophic lateral sclerosis
British Journal of Pharmacology

Clinical and preclinical evidence of somatosensory involvement in amyotrophic lateral sclerosis
British Journal of Pharmacology

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc−
Pharmacology Research & Perspectives

Leucine‐rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes
Pharmacology Research & Perspectives

Impact of deprivation, dementia prevalence and regional demography on prescribing of antidementia drugs in England: A time trend analysis
British Journal of Clinical Pharmacology

Safety, pharmacokinetics and pharmacodynamics of SBT‐020 in patients with early stage Huntington's disease, a 2‐part study
British Journal of Clinical Pharmacology

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