Joint Societies Article Collection
Reflecting the increasingly interdisciplinary nature of life science research, this collection brings together articles published in the journals from 5 of the leading Societies in the field. Key themes highlighted include Cardiovascular disease, Experimental models/ organoids, Healthy aging, Ion channels in health & disease, Neurodevelopment, Sex differences, Sustainable research and Viral pathogenesis with a focus on COVID and respiratory diseases/ infections.
Cardiovascular disease
Zebrafish as a tractable model of human cardiovascular disease
British Journal of Pharmacology
Phenotyping heart failure using model-based analysis and physiology-informed machine learning
The Journal of Physiology
Molecular mechanisms underlying fructose-induced cardiovascular disease: exercise, metabolic pathways and microRNAs
Experimental Physiology
Regional functional and structural abnormalities within the aorta as a potential driver of vascular disease in metabolic syndrome
Experimental Physiology
Effect of high-intensity interval training on cardiometabolic component risks in persons with paraplegia: Protocol for a randomized controlled trial
Experimental Physiology
REM sleep latency as an independent risk for cardiovascular events in hemodialysis patients
Physiological Reports
Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?
Bioscience Reports
Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women
Clinical Science
Short-chain fatty acid, acylation and cardiovascular diseases
Clinical Science
Mineralocorticoid receptor actions in cardiovascular development and disease
Essays in Biochemistry
Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities
Biochemical Society Transactions
Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection
British Journal of Pharmacology
The NO signalling pathway in aortic aneurysm and dissection
British Journal of Pharmacology
Endothelial TRPV4–eNOS coupling as a vital therapy target for treatment of hypertension
Biochemical Society Transactions
Experimental models/ organoids
Animal models of Parkinson’s disease: a guide to selecting the optimal model for your research
Neuronal Signaling
Lipid profiling of mouse intestinal organoids for studying APC mutations
Bioscience Reports
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids
Biochemical Journal
Modelling the central nervous system: tissue engineering of the cellular microenvironment
Emerging Topics in Life Sciences
Identification of TGFβ signaling as a regulator of interneuron neurogenesis in a human pluripotent stem cell model
Neuronal Signaling
Trefoil factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids
The Journal of Physiology
Effects of aerobic exercise on lipopolysaccharide-induced experimental acute lung injury in the animal model of type 1 diabetes mellitus
Experimental Physiology
Inhibition of anandamide hydrolysis does not rescue respiratory abnormalities observed in an animal model of Parkinson's disease
Experimental Physiology
Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy
Experimental Physiology
Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: An experimental ovine study
Physiological Reports
Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology
British Journal of Pharmacology
Anti‐arrhythmic investigations in large animal models of atrial fibrillation
British Journal of Pharmacology
Healthy aging
Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthy
British Journal of Pharmacology
Commentary on the EMA reflection paper on the pharmaceutical development of medicines for use in the older population
British Journal of Clinical Pharmacology
Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways
British Journal of Pharmacology
Short-term ketone monoester supplementation improves cerebral blood flow and cognition in obesity: A randomized cross-over trial
The Journal of Physiology
Vascular calcium signalling and ageing
The Journal of Physiology
Physiological complexity: influence of ageing, disease and neuromuscular fatigue on muscle force and torque fluctuations
Experimental Physiology
Impact of early life development on later onset chronic kidney disease and hypertension and the role of evolutionary trade-offs
Experimental Physiology
The role of physical activity and miRNAs in the vascular aging and cardiac health of dialysis patients
Physiological Reports
Targeting mitochondrial fitness as a strategy for healthy vascular aging
Clinical Science
Manipulating the exposome to enable better ageing
Biochemical Journal
Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction
Neuronal Signaling
Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease
Bioscience Reports
Estrogen receptors and the aging brain
Essays in Biochemistry
Ageing, sex, and cardioprotection
British Journal of Pharmacology
Sirtuins as pharmacological targets in neurodegenerative and neuropsychiatric disorders
British Journal of Pharmacology
Emerging therapies and their delivery for treating age‐related macular degeneration
British Journal of Pharmacology
Mineralocorticoid pathway in retinal health and diseases
British Journal of Pharmacology
Ion channels in health & disease
cGMP and mitochondrial K+ channels—Compartmentalized but closely connected in cardioprotection
British Journal of Pharmacology
A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel
The Journal of Physiology
Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension
The Journal of Physiology
Localization of Na+ channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study
The Journal of Physiology
Tracing oral Na+ and K+ in sweat during exercise and recovery in horses
Experimental Physiology
Age-dependent decrease in TRPM4 channel expression but not trafficking alters urinary bladder smooth muscle contractility
Physiological Reports
Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function
Clinical Science
Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Nav1.5
Biochemical Journal
Role of protons in calcium signaling
Biochemical Journal
Ion channels as convergence points in the pathology of pulmonary arterial hypertension
Biochemical Society Transactions
Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease
Essays in Biochemistry
Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels
British Journal of Pharmacology
Ca2+ signalling in fibroblasts and the therapeutic potential of KCa3.1 channel blockers in fibrotic diseases
British Journal of Pharmacology
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR
British Journal of Pharmacology
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice
British Journal of Pharmacology
Neurodevelopment
Axonal excitability changes in children with spinal muscular atrophy treated with nusinersen
The Journal of Physiology
The impact of preterm adversity on cardiorespiratory function
Experimental Physiology
The non-coding genome in genetic brain disorders: new targets for therapy?
Essays in Biochemistry
Mutations in genes encoding regulators of mRNA decapping and translation initiation: links to intellectual disability
Biochemical Society Transactions
Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells
Bioscience Reports
A role for TGFβ signalling in medium spiny neuron differentiation of human pluripotent stem cells
Neuronal Signaling
Cortical cells are altered by factors including bone morphogenetic protein released from a placental barrier model under altered oxygenation
Neuronal Signaling
Sex differences
Current challenges in the treatment of cardiac fibrosis: recent insights into the sex-specific differences of glucose-lowering therapies on the diabetic heart: IUPHAR Review 33
British Journal of Pharmacology
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self-administration: Sex differences in rats
British Journal of Pharmacology
Sex-related differences in COVID-19 lethality
British Journal of Pharmacology
Sex: A change in our guidelines to authors to ensure that this is no longer an ignored experimental variable
British Journal of Pharmacology
Sex‐dependent effects of endocannabinoid modulation of conditioned fear extinction in rats
British Journal of Pharmacology
Sexual dimorphism in prostacyclin‐mimetic responses within rat mesenteric arteries: A novel role for KV7.1 in shaping IP receptor‐mediated relaxation
British Journal of Pharmacology
Individualized medicine: Sex, hormones, genetics, and adverse drug reactions
Pharmacology Research & Perspectives
The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs
Pharmacology Research & Perspectives
Physiological and molecular sex differences in human skeletal muscle in response to exercise training
The Journal of Physiology
Sexual dimorphism in liver cell cycle and senescence signalling pathways in young and old rats
The Journal of Physiology
Age and sex differences in blood pressure responses during hyperpnoea
Experimental Physiology
Sex differences in the coronary vascular response to combined chemoreflex and metaboreflex stimulation in healthy humans
Experimental Physiology
Sex differences in anatomic plasticity of gut neuronal–mast cell interactions
Physiological Reports
Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction
Clinical Science
Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice
Neuronal Signaling
Meiosis initiation: a story of two sexes in all creatures great and small
Biochemical Journal
Sex differences in immune responses to SARS-CoV-2 in patients with COVID-19
Bioscience Reports
Sustainable research
Sustainable medicines development and use: Our collective responsibility for action to mitigate the natural world crisis
British Journal of Clinical Pharmacology
Sustainable medicines use in clinical practice: A clinical pharmacological view on eco-pharmaco-stewardship
British Journal of Clinical Pharmacology
Recent Developments in sustainably sourced Protein -Based biomaterials
Biochemical Society Transactions
Practical considerations for delivering on the sustainability promise of fermentation-based biomanufacturing
Emerging Topics in Life Sciences
Synthetic biology approaches towards the recycling of metals from the environment
Biochemical Society Transactions
Technologies enabling rapid crop improvements for sustainable agriculture: example pennycress (Thlaspi arvense L.)
Emerging Topics in Life Sciences
Saccharomyces cerevisiae strains used industrially for bioethanol production
Essays in Biochemistry
Viral pathogenesis - focus on COVID and respiratory diseases/ infections
Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology
British Journal of Pharmacology
The hidden role of NLRP3 inflammasome in obesity-related COVID-19 exacerbations: Lessons for drug repurposing
British Journal of Pharmacology
Potential therapeutic targets and promising drugs for combating SARS-CoV-2
British Journal of Pharmacology
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro
British Journal of Pharmacology
The impact of COVID‐19 on pregnancy and therapeutic drug development
British Journal of Pharmacology
COVID-19 is getting on our nerves: sympathetic neural activity and haemodynamics in young adults recovering from SARS-CoV-2
The Journal of Physiology
Silent hypoxaemia in COVID-19 patients
The Journal of Physiology
Human models for COVID-19 research
The Journal of Physiology
Hypoxia induces expression of angiotensin-converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID-19
Physiological Reports
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
Biochemical Journal
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19
Bioscience Reports
Transmission and prevention of SARS-CoV-2
Biochemical Society Transactions
How SARS-CoV-2 (COVID-19) spreads within infected hosts — what we know so far
Emerging Topics in Life Sciences